Diseases

Congenital cholestasis

Intrahepatic cholestasis is a pregnancy-specific condition, as indicated by the term "pregnancy". It corresponds to a dysregulation of the liver which causes a decrease in biliary secretion by involvement of the liver cells.

Congenital cholestasis is manifested by itching, an elevation of bile acids in the blood (serum) with fetal prognosis in many cases. The causes of cholestasis of pregnancy are complex and not fully understood. However, it appears to result from the effect of steroid hormones in pregnancy in patients with preexisting genetic background.

Congenital cholestasis can be serious, especially for the fetus. The mechanisms of occurrence of fetal complications are also poorly understood. Ursodeoxycolic acid (UDCA) treatment is currently recognized by all. If pregnancy cholestasis persists despite treatment, or is diagnosed too late, it may be necessary to initiate pregnancy before its completion. This, to protect the fetus.

The pregnancy cholestasis is far from exceptional, and affects, in France, about five pregnant women per thousand, it is more frequent in case of multiple pregnancy. It appears most often in the 3rd trimester of pregnancy, after 30 weeks of amenorrhea. Some recurring cases may begin in the 2nd quarter, but this is quite exceptional.

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