Medicinal Products

DOXYCYCLINE MYLAN 100 mg

Generic drug of Vibramycin N
Therapeutic class: Dermatology
Active ingredients: Doxycycline
laboratory: Mylan

Tablet breackable
Box of 30
All forms

Indication

They derive from both the antibacterial activity and the pharmacokinetic properties of doxycycline.

They take into account both the situation of this antibiotic in the range of antibacterial products currently available and up-to-date knowledge of the resistance of bacterial species.

They are limited to the following infections:

· Brucellosis,

· Pasteurellosis,

· Chlamydiae pulmonary, genitourinary and ophthalmic infections,

· Pulmonary infections, genitourinary mycoplasma,

· Rickettsioses

· Coxiella burnetii (Q fever),

· Gonorrhea,

· ENT and bronchopulmonary infections with Haemophilus influenzae, in particular acute exacerbation of chronic bronchitis,

· Treponemes, (in syphilis, tetracyclines are only indicated in cases of beta-lactam allergy),

· Spirochetes (Lyme disease, leptospirosis),

· Cholera,

· Medium and severe inflammatory acne and inflammatory component of mixed acnes.

Special situations

Post-exposure prophylaxis and curative treatment of anthrax.

Official recommendations concerning the appropriate use of antibacterials should be taken into account.

Dosage DOXYCYCLINE MYLAN 100 mg scored tablet Box of 30

Dosage

adults

· Subjects weighing more than 60 kg
200 mg a day in one dose

· Subjects weighing less than 60 kg
200 mg the first day
100 mg the following days in one take

Special cases:

· Acute gonorrhea

o male adults

§ 300 mg on day 1 (twice taken) followed by 200 mg daily for 2 to 4 days

§ or a 500 mg minute treatment or 2 doses of 300 mg given 1 hour apart

o female adults

§ 200 mg daily

· Primary and secondary syphilis

o 300 mg daily in 3 taken for at least 10 days

· Uncomplicated urethritis, endocervicitis, proctitis due to Chlamydia trachomatis

o 200 mg daily in 3 taken for at least 10 days

· Acne

o 100 mg daily for at least 3 months. In some cases, a half-dose treatment may be used.

Special situations

Anthrax disease: post-exposure prophylaxis and curative treatment of symptomatic people who can receive oral treatment either immediately or in combination with parenteral therapy: 200 mg daily in 2 doses.

The duration of treatment is 8 weeks when exposure to charcoal is proven.

Children over 8 years old

· 4 mg / kg / day

Special situations

Anthrax disease: post-exposure prophylaxis and curative treatment of symptomatic people who can receive oral treatment, either immediately or in combination with parenteral therapy: 4 mg / kg / day in two doses without exceeding

Adult dosage (200 mg / day).

The duration of treatment is 8 weeks when exposure to charcoal is proven.

Administration mode

Administer in the middle of a meal with a glass of water (100 ml) and at least one hour before bedtime.

Against indications

This medicine MUST NEVER BE USED in the following situations:

· In case of allergy to antibiotics of the family of tetracyclines,

· In children under eight years of age due to the risk of permanent staining of teeth and hypoplasia of tooth enamel,

· In combination with systemic retinoids (see section Interactions with other medicinal products and other forms of interaction ),

· In pregnant women from the 2nd trimester of pregnancy (see section Pregnancy and breastfeeding ).

· In case of bowel obstruction due to the presence of castor oil.

This medicine SHOULD NOT BE USED:

During breastfeeding.

Doxycycline Mylan side effects

Skin and subcutaneous tissue disorders

Photosensitivity reactions, rash, very rare cases of erythroderma.

Renal and urinary disorders

Extra-renal hyperazotemia related to anti-anabolic effect and may be increased by association with diuretics has been reported with tetracyclines. This hyperazotemia has not been observed to date with doxycycline.

Immune system disorders

Allergic reactions (urticaria, rash, pruritus, angioedema, anaphylactic reaction, rheumatoid purpura, pericarditis, exacerbation of preexisting lupus erythematosus).

Nervous system disorders

Benign intracranial hypertension in adults has been reported during treatment with tetracyclines. Therefore, treatment should be discontinued if an increase in intracranial tension is suspected or observed during doxycycline treatment.

Gastrointestinal disorders

Dental dyschromia or enamel hypoplasia when administered in children under 8 years of age.

Digestive disorders (nausea, epigastralgia, diarrhea, anorexia, glossitis, enterocolitis, anal or genital candidiasis).

Possible occurrence of dysphagia, oesophagitis, oesophageal ulcerations, favored by lying down and / or with a small amount of water.

Blood and lymphatic system disorders

Cases of haematological disorders have been described during treatment with tetracyclines (haemolytic anemia, thrombocytopenia, neutropenia, eosinophilia).

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