Generic drug of the therapeutic class: Dermatology
active ingredients: Betamethasone, Neomycin
15 g tube
Initial treatment, for less than 8 days, of a corticosensitive dermatosis in case of superinfection by a neomycin-sensitive organism.
Official recommendations concerning the appropriate use of antibacterials should be taken into account.
SPECTRUM OF BACTERIAL ACTIVITY:
- sensitive species:
. Gram-positive aerobes: Corynebacterium, Listeria monocytogenes, Staphylococcus méti-S.
. Gram-negative aerobes: Acinetobacter (mainly Acinetobacter baumannii ), Branhamella catarrhalis, Campylobacter, Citrobacter freundii, Citrobacter koseri, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Klebsiella, Morganella morganii, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Salmonella, Serratia, Shigella, Yersinia .
- moderately sensitive species (in vitro of intermediate sensitivity):
. Gram-negative aerobes: Pasteurella .
Dosage DIPROSONE NEOMYCINE Ointment Tube 15 g
1 to 2 applications per day in thin layer, followed by a light massage. An increase in the number of daily applications could aggravate the adverse effects without improving the therapeutic effects. The product should not be used over a large area and the duration of treatment should not exceed 8 days.
This ointment form is not suitable for the treatment of oozing lesions, macerated and folds because of its occlusive nature.
Hypersensitivity to one of the components of the preparation, especially neomycin.
- Primitive bacterial, viral, fungal or parasitic infections.
- Ulcerated lesions.
- Application on the eyelids (risk of glaucoma).
- Child under 2 years old, because of the risk of percutaneous passage of neomycin and therefore the risk of ototoxicity.
- Breast lesions, during breastfeeding, because of the risk of ingestion of the product by the newborn (see pregnancy and breastfeeding).
NOT RECOMMENDED :
- Pregnancy: given the presence in this specialty of an aminoglycoside, neomycin, causing an ototoxic risk, and the possibility of a systemic passage, the use of this drug in women pregnant is not recommended.
- Breast-feeding: in the absence of data on the passage of this medicine in breast milk, its use should be avoided; in particular, do not apply to breasts during breastfeeding, because of the risk of ingestion of the product by the newborn.
Adverse effects Diprosone Neomycin
- Due to the corticosteroid :
They are rare in case of short treatment.
. In the face, corticosteroids can create perioral dermatitis or aggravate rosacea (see warnings and contraindications).
. It can be observed a delay of healing of unstressed wounds, pressure ulcers, leg ulcers (see contraindications).
. Potential systemic effects (see warnings).
. Acneiform or pustular eruptions, hypertrichosis, depigmentations have been reported.
. Secondary infections, especially under occlusive dressing or in folds, and allergic contact dermatoses have also been reported with the use of local corticosteroids.
. Prolonged use of corticosteroids with strong activity may result in skin atrophy, telangiectasia (to be particularly feared on the face), stretch marks (at the root of the limbs in particular, and occurring more readily in adolescents), a secondary ecchymotic purpura to atrophy, skin fragility.
- Due to neomycin :
. Possibility of allergic eczema of contact. It occurs more frequently when applied to stasis dermatitis, particularly peri-ulcerous, for prolonged use greater than 8 days, when used under occlusion. Eczema lesions can spread remotely from treated areas.
. Allergy can be crossed with other aminoglycoside antibiotics.
. Possibility of systemic effects if the treated surface is very extensive, damaged skin, prolonged use.