Generic drug from Dilrene LP GE
Therapeutic class: Cardiology and angiology
Active ingredients: Diltiazem
laboratory: EG Labo
Extended release gene
box of 30
Â · Arterial hypertension.
Dosage DILTIAZEM EG LP 300 mg long-release capsule box of 30
Â · Arterial hypertension.
This medicine should never be used in case of:
· Hypersensitivity to diltiazem,
· Sinus dysfunction,
Â · Atrioventricular blocks of degrees II and III not fitted,
Left ventricular failure with pulmonary stasis,
Severe bradycardia (less than or equal to 40 beats per minute),
· Combination with dantrolene as an infusion, cisapride, dihydroergotamine, ergotamine, pimozide (see section 4.5, Interactions with other medicinal products and other forms of interaction ).
Diltiazem hydrochloride is generally discouraged when combined with antiarrhythmics and esmolol (if left ventricular function is impaired) in pregnant women or women who may be pregnant (see section on Pregnancy and breastfeeding ).
Adverse effects Diltiazem Lp Eg
Classification of undesirable effects according to expected frequencies: very common (≥ 1/10); Frequency (≥ 1/100, <1/10) not very frequent (≥ 1/1000, <1/100); rare (≥ 1/10 000, <1/1000); very rare (<1 / 10, 000); undefined frequency (can not be estimated on the basis of available data).
Within each group frequency, the undesirable effects are presented in a decreasing order of gravity.
· Frequent: atrioventricular blocks (may be 1 st, 2 nd or 3 rd degree, possible branch blocks), palpitations.
· Not very common: bradycardia.
· Uncertain frequency: Sino-atrial blocks and congestive heart failure.
The manifestations corresponding to vasodilatation (cephalads, vasomotor flushes and in particular lower limb edema) are dose-dependent, related to the pharmacological activity of the active ingredient. They occur more readily in the elderly subject.
· Frequent: flushing.
· Not common: orthostatic hypotension.
· Uncontrolled frequency: vasculitis (including leukocytoclastic vasculitis).
· Frequent: constipation, dyspepsia, eczastralgia, nausea.
· Not very common: vomiting, diarrhea.
· Rare: buccal dryness.
· Uncontrolled frequency: Gingival hyperplasia.
Skin and subcutaneous tissue disorders
· Frequent: rhythm.
· Rare: hives.
· Uncontrolled frequency: Quincke's disease, rash, polymorphic rheumatism (including Steven-Johnson syndrome and toxic epidermal necrosis), exfoliative dermatitis, acute exanthematous pustulosis "Generalized, photosensitivity reactions (including lichenoid kerosis on areas of skin exposed to the sun), sweating, rhythms that may possibly be fribrile and / or desquamative.
· Not very common: isolated, moderate and transient general rule increases, hemostatic enzymes (ASAT, ALT, LDH, alkaline phosphatase) have been reported observed in the initial period of treatment.
· Unlimited frequency: reversible clinical hepatitis at the end of treatment.
Nervous system disorders
· Frequent: headache, dizziness.
· Unpecified frequency: extrapyramidal symptoms usually reversible upon discontinuation of treatment.
· Not very common: nervousness, insomnia.
· Uncertain frequency: mood changes (especially depression).
Reproductive system disorders
· Uncertained frequency: Gynecomasties generally reversible at the end of the treatment.
General disorders and administration site abnormalities
· Very frequent: oedemas of the lower limbs.
· Frequent: malaise, asthenia.
Blood and lymphatic system disorders
Â · Uncontrolled frequency: thrombocytopenia.