Medicinal Products


Generic drug of the therapeutic class: Pneumology
active ingredients: Theophylline
laboratory: Serp

Bottle (+ measuring spoon of 10 ml graded to 5 ml) of 200 ml
All forms


Symptomatic treatment of persistent asthma and other obstructive bronchopathies.

Dosage DILATRANE 1% Syrup Bottle (+ measuring spoon of 10 ml graduated to 5 ml) of 200 ml

The dosage will be adapted to the individual susceptibility according to the therapeutic effect and the undesirable effects.
Treatment will be started with a moderate initial dose to test individual tolerance, which will then be gradually adjusted by increasing or decreasing the dose in stages until a therapeutic effect is achieved without adverse effects.
As plasma levels reach at least a steady state after 3 consecutive days of well-conducted therapy, this minimum time should be respected to judge the therapeutic effect before each dose increase.
In case of therapeutic insufficiency and in the absence of any sign of intolerance, the dose will be gradually increased under control of theophyllinaemia, in steps of 2 mg / kg / day.
In children older than 30 months, below a daily dose of 16 mg / kg / day (adapted for obesity at the ideal weight) and not exceeding, in any case, 400 mg / day and in the absence of risk factors for decreasing plasma clearance, control of theophylline is not essential for the safety of the product.
Theophylline plasma concentrations effective on bronchodilation range between 8 and 20 μg / ml.
The toxicity threshold of theophyllinemia is 20 μg / ml.
Use the measuring spoon graduated to 5 ml and 10 ml.
A dose of 5 ml contains 50 mg theophylline.
A dose of 10 ml contains 100 mg theophylline.
For information :
- Child over 30 months old:
Usually effective dosage: 10 to 12 mg / kg daily
The daily dosage will be divided into 4 doses.
- Adult :
Usually effective dosage: 7 to 12 mg / kg / day without exceeding 800 mg per day.
The daily dosage will be divided into 3 doses.
In case of obesity, the dosage will be adapted to the ideal weight (average weight compared to the size measured on standard growth and weight growth curves).
Administration mode :
Oral way.

Against indications

CONTRAINDICATED: This drug is contraindicated in the following cases:
- intolerance to theophylline,
- child under 30 months,
- acute intermittent porphyria, - association with troleandomycin and enoxacin.
- Breast-feeding: Theophylline passes into breast milk, which may cause hyperexcitability in the newborn. Therefore, breastfeeding is not recommended during treatment with theophylline.
- This medicine is not recommended in combination with erythromycin and viloxazine.

Dilatrane side effects

- nausea, vomiting, epigastric pain,
- headache, excitement, insomnia,
- tachycardia.
These side effects may be the first signs of an overdose. The appearance of convulsion is the sign of confirmed intoxication, but may be the first sign, especially in children.
In children with gastroesophageal reflux, theophylline may increase reflux.
Rarely: possibility of gastrointestinal ulceration with haemorrhage and occlusive syndrome.

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