Medicinal Products


Generic drug of the therapeutic class: Dermatology
active ingredients: Adapalene
laboratory: Galderma Internat

30 g tube
All forms


Acne of medium severity, particularly indicated in retention acne.

Dosage DIFFERINE 0.1% Cream Tube 30 g

Apply the value of a cream pea by spreading it over the acne lesions by avoiding the eyes and lips, once a day before bedtime after washing and thoroughly drying the skin.
The clinical improvement should be visible after 4 to 8 weeks of treatment, with a clear improvement after 3 months of treatment. The tolerance of adapalene cream has been demonstrated over a period of 6 months of treatment. It is recommended to evaluate the improvement of the patient after 3 months of treatment.
If the treatment is stopped or the frequency of application decreases due to irritation, the rate of application can be resumed or increased according to the patient's tolerance to treatment.
An increase in the amounts applied would neither improve the activity nor the speed of action of the product but could cause redness, peeling and discomfort.

Against indications

Hypersensitivity to one of the components.
- Pregnancy: Like all retinoids, adapalene is teratogenic orally. Teratogenic studies performed in rats and rabbits, topically, with doses 200 times higher than the human dose have not shown any teratogenic effect. In the human species, considering the existence of a percutaneous passage (even if it is weak) and of the absence of clinical data, the use is disadvised during the pregnancy.
- Breast-feeding: Do not apply on the breast while breastfeeding.

Differin adverse effects

Reversible skin irritation may occur, disappearing when treatment is discontinued or applications are spaced apart. A feeling of warmth or a slight tingling may occur after application.

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