Medicinal Products

BI-MISSILOR Ge 1.5 MUI / 250 mg

Generic drug of Birodogyl
Therapeutic class: Infectiology - Parasitology
active ingredients: Spiramycin, Metronidazole
laboratory: Pierre Fabre Medicament

Coated tablet
Box of 10
All forms

Indication

They arise from the antibacterial activity and pharmacokinetic characteristics of this drug. They take into account both the clinical studies that the drug has given and its place in the range of antibacterial products currently available.
- Cure :
Indications are limited to acute, chronic or recurrent stomatologic infections:
. dental abscesses, phlegmons, perimaxillary cellulitis, pericoronitis,
. gingivitis, stomatitis,
. periodontitis,
. parotidites, submaxillites.
- Preventive treatment :
Preventive treatment of local postoperative infectious complications in odonto-stomatological surgery.
- Efficacy in the prevention of infectious endocarditis has not been demonstrated.
- Official recommendations regarding the proper use of antibacterials should be taken into account.

Dosage BI-MISSILOR Ge 1.5 MUI / 250 mg Film-coated tablet Box of 10

- Cure :
CHILD OVER 15 YEARS AND ADULT:
. 2 to 3 tablets daily in 2 or 3 doses, during meals (ie: 3 to 4.5 MIU of spiramycin and 500 to 750 mg of metronidazole).
. In severe cases, the dosage may be increased to 4 tablets per day.
- Preventive treatment of local postoperative infectious complications in odonto-stomatological surgery:
CHILD OVER 15 YEARS AND ADULT: 2 to 3 tablets daily in 2 or 3 shots, during meals.

Against indications

CONTRAINDICATED:
This medicine MUST NEVER BE USED in the following cases:
- hypersensitivity to imidazoles, spiramycin and / or any of the excipients,
- children under 15 years old.
NOT RECOMMENDED :
- This medicine is generally NOT recommended in combination with disulfiram and alcohol or drugs containing it (see section on interactions).
- Very rare cases of haemolytic anemia have been reported in patients with Glucose-6-phosphate dehydrogenase deficiency, the use of spiramycin in this patient population is not recommended.
- Breast-feeding: As metronidazole and spiramycin pass into breast milk, avoid administration of this drug while breastfeeding.

Side effects BI-Missilor GE

RELATED TO SPIRAMYCIN :
- Gastrointestinal system:
gastralgia, nausea, vomiting, diarrhea and very rare cases of pseudomembranous colitis.
- Skin and appendices:
. rashes, urticaria, pruritus.
. very rarely Quincke's edema, anaphylactic shock.
. Very rare cases of acute generalized exanthematous pustulosis (see section on warnings and precautions for use).
- Central and peripheral nervous system:
occasional and transient paresthesia.
- Liver manifestations:
very rare cases of liver test abnormalities.
- Blood line:
very rare cases of haemolytic anemia have been reported (see section on warnings and precautions for use).
RELATED TO METRONIDAZOLE :
- Gastrointestinal system:
. benign digestive disorders (epigastric pain, nausea, vomiting, diarrhea),
. glossitis with dryness of mouth, stomatitis, metallic taste, anorexia,
. exceptionally, cases of reversible pancreatitis upon discontinuation of treatment.
- Skin and appendices:
. flushing, pruritus, sometimes feverish rash;
. urticaria, angioedema, exceptionally anaphylactic shock.
- Central and peripheral nervous system:
. headache,
. peripheral sensory neuropathies,
. convulsions, vertigo, ataxia.
- Psychiatric disorders:
confusion, hallucinations.
- Blood line:
very rare cases of neutropenia, agranulocytosis, and thrombocytopenia.
- Liver manifestations:
very rare cases of reversible abnormalities of hepatic function and cholestatic hepatitis.
- Various:
appearance of a reddish brown color of the urine due to the presence of water-soluble pigments from the metabolism of the product.

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