Medicinal Products

BENAZEPRIL HYDROCHLOR ACTAVIS 10 mg / 12.5 mg

Generic drug of Briazide
Therapeutic class: Cardiology and angiology
active ingredients: Hydrochlorothiazide, Benazepril
laboratory: Arrow Generic

Divisible coated tablet
Box of 90
All forms

Indication

· Treatment of high blood pressure in case of therapeutic failure of monotherapy with a conversion enzyme inhibitor.

Dosage BENAZEPRIL HYDROCHLOR ACTAVIS 10 mg / 12.5 mg Breakable film-coated tablet Box of 90

Each tablet contains 10 mg benazepril and 12.5 mg hydrochlorothiazide.

Normal renal function : The usual dosage is one tablet taken once a day.

Renal insufficiency :

· Creatinine clearance greater than or equal to 30 ml / min: the usual starting dose is one tablet daily.
In these patients, normal medical practice includes a periodic control of potassium and creatinine, for example every two months in times of therapeutic stability;

· Creatinine clearance <30 ml / min or serum creatinine greater than 250 μmol / l: contraindication.

Elderly : It is recommended to initiate the treatment at the dosage of half a tablet.

Against indications

Related to benazepril

This medicine should never be used in case of:

Hypersensitivity to benazepril,

· History of angioedema (angioedema) associated with the use of an angiotensin-converting enzyme inhibitor,

· In the 2nd and 3rd trimesters of pregnancy (see sections Warnings and precautions for use and Pregnancy and lactation ),

· In case of bowel obstruction due to the presence of castor oil.

Hydrochlorothiazide-related

This medicine should never be used in the following cases:

· Hypersensitivity to sulfonamides,

· Severe renal impairment (creatinine clearance less than 30 ml / min),

· Hepatic encephalopathy.

Related to benazepril

This medicine is generally not recommended in case of:

· Combinations with potassium-sparing diuretics, potassium salts, estramustine and lithium (see section Interactions with other medicinal products and other forms of interaction ),

Bilateral stenosis of the renal artery or functionally unique kidney,

· Hyperkalemia.

Hydrochlorothiazide-related

This drug is generally not recommended for combination with lithium and non-anti-arrhythmic drugs giving torsades de pointes (see section 4.5 ).

Side effects Benazepril Hydrochlor Actavis

Related to benazepril

Clinically

Have been found:

· Headache, asthenia, vasomotor reactions, dizziness, palpitations,

Hypotension, orthostatic or not (see section Warnings and precautions for use ),

· Rash, pemphigus, Stevens-Johnson syndrome,

· Digestive disorders especially due to the presence of castor oil (nausea, vomiting, abdominal pain), dysgeusia,

· Isolated cases of liver injury,

· Dry cough has been reported with the use of angiotensin-converting enzyme inhibitors. It is characterized by its persistence as well as its disappearance at the end of treatment. The iatrogenic etiology should be considered in the presence of this symptom.

Exceptionally:

· Angioedema (Quincke's edema) (see Warnings and precautions for use ).

Biologically

· Moderate increase in urea and plasma creatinine, reversible upon discontinuation of treatment. This increase is more frequently encountered in cases of stenosis of the renal arteries, arterial hypertension treated with diuretics, renal failure.

· In case of glomerular nephropathy, administration of a conversion enzyme inhibitor may cause proteinuria.

· Hyperkalemia, usually transient.

· Anemia (see Warnings and Precautions ) has been reported with angiotensin-converting enzyme inhibitors on specific sites (kidney transplant, hemodialysis). Hemolytic anemia has been observed.

Hydrochlorothiazide-related

Clinically

· In case of hepatic insufficiency, possibility of occurrence of hepatic encephalopathy (see sections Contraindications and Warnings and precautions for use ).

· Hypersensitivity reactions, mainly dermatological, in subjects predisposed to allergic and asthmatic reactions.

· Possibility of worsening of pre-existing systemic lupus erythematosus, necrotizing vasculitis, exceptional Lyell syndrome.

· Uncommon: Cases of photosensitivity reaction have been reported (see Warnings and Precautions section ).

· Nausea, constipation, dizziness, asthenia, paresthesia, headache rarely seen and usually giving way to a reduction in dosage.

· Exceptionally: pancreatitis, visual disturbances at the beginning of treatment.

Biologically

· Potassium depletion with hypokalemia, especially in cases of intensive diuresis, and particularly severe in some at-risk populations (elderly, malnourished, cirrhotic, coronary, heart failure).

· Hyponatremia with hypovolemia leading to dehydration and orthostatic hypotension, or even confusional syndrome.
The concomitant loss of chlorine ions may secondarily cause a compensatory metabolic alkalosis: the incidence and the amplitude of this effect are small.

· A rise in serum uric acid and blood glucose during treatment: the use of these diuretics will be carefully discussed in gouty and diabetic subjects.

· An increase in plasma lipids at a high dose.

Hematologic disorders, much rarer, thrombocytopenia, leukopenia, agranulocytosis, bone marrow aplasia, haemolytic anemia.

· Hypercalcemia exceptional.

Popular Posts

Category Medicinal Products, Next Article