Medicinal Products

ATENOLOL MYLAN 50 mg

Generic drug of Tenormine
Therapeutic class: Cardiology and angiology
active ingredients: Atenolol
laboratory: Mylan

Divisible coated tablet
Box of 90
All forms

Indication

- Hypertension.
This dosage is particularly suitable in patients with renal insufficiency, in which the dosage should be adjusted to the degree of renal insufficiency.
- Supraventricular arrhythmias:
. paroxysmal supraventricular tachycardias (as preventive or curative treatment);
. atrial fibrillation or flutter in case of insufficient response to digitalis at maximum doses and in cases where digitalis are contraindicated or have an adverse benefit / risk ratio.
- Ventricular arrhythmias:
. ventricular extrasystoles (preventive or curative treatment) in case of extrasystoles resulting from an increase in sympathetic activity;
. ventricular tachycardias and ventricular fibrillations (preventive treatment), especially when the ventricular anomaly results from significant sympathetic activity.

Dosage ATENOLOL MYLAN 50 mg Film-coated tablet scored box of 90

- Hypertension: The recommended dose is 100 mg once daily (2 tablets at 50 mg).
However, in cases of severe hypertension, a higher dosage may be necessary.
The combination with other antihypertensive therapies, for example with diuretics, is possible. - Rhythmic disorders: After controlling rhythm disorders with atenolol administered intravenously (if indicated), atenolol will be administered orally and the recommended maintenance dose is 50 to 100 mg / day. - In case of renal insufficiency, the dosage is adjusted to the values ​​of serum creatinine or creatinine clearance according to the table below:
Serum creatinine / creatinine clearance (Clcr): Dosage. . <25 mg / L = = 35 ml / min / 1.73 m²: unchanged (2 x 50 mg / d) once.
. 25-50 mg / L = 0.3-0.6 mmol / L / 15 <= Clcr <35 ml / min / 1.73 m²: 1 x 50 mg / day.
. > 50 mg / L => 0.6 mmol / L / <15 ml / min / 1.73 m²: 1 x 25 mg / day, ie 1/2 tablet per day ATENOLOL MYLAN 50 mg or 1 x 50 mg all the 2 days.
. Chronic hemodialysis: treatment initiated in hospital: 50 mg after each session.

Against indications

CONTRAINDICATED:
This medicine MUST NEVER be used in the following cases:
- hypersensitivity to atenolol,
- asthma and obstructive chronic bronchopneumopathies in their severe forms,
- heart failure not controlled by treatment,
- cardiogenic shock,
- atrioventricular blocks of the second and third degrees not paired,
- Prinzmetal's angina (in pure forms and monotherapy),
- sinus disease (including sinoatrial block),
- bradycardia (<45-50 beats per minute),
- Raynaud's phenomenon and peripheral arterial disorders in their severe forms,
- untreated pheochromocytoma,
- hypotension,
- history of anaphylactic reaction,
- combination with floctafenine, sultopride (see interactions).
NOT RECOMMENDED :
- This drug is generally not recommended when combined with amiodarone (see interactions).
- Breast-feeding: Beta-blockers are excreted in the milk. The risk of developing hypoglycaemia and bradycardia has not been evaluated. Therefore, as a precaution, it should be avoided in women who are breastfeeding.

Atenolol Mylan side effects

CLINICAL PLAN :
- The most frequently reported:
. asthenia,
. cooling of the ends,
. bradycardia, severe if any,
. digestive disorders (gastralgia, nausea, vomiting),
. incapacity.
- Much more rarely:
. slowing of atrioventricular conduction or intensification of an existing atrioventricular block,
. heart failure,
. blood pressure drop,
. bronchospasm,
. hypoglycemia,
. Raynaud's syndrome,
. worsening of existing intermittent claudication,
. various skin manifestations including psoriasiform eruptions.
AT THE BIOLOGICAL PLAN :
In rare cases, it has been possible to observe the appearance of antinuclear antibodies which only exceptionally accompany clinical manifestations such as lupus syndrome and cede at the end of treatment.
Exceptional elevations of hepatic transaminases (as well as some cases of intrahepatic cholestasis).

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