Medicinal Products

ATENOLOL GNR 50 mg

Generic drug of Tenormine
Therapeutic class: Cardiology and angiology
active ingredients: Atenolol
laboratory: Sandoz

Divisible coated tablet
Box of 28
All forms

Indication

Hypertension.
This dosage is particularly suitable in patients with renal insufficiency, in which the dosage should be adjusted to the degree of renal insufficiency.

Dosage ATENOLOL GNR 50 mg Film-coated tablet scored box of 28

- Hypertension:
The recommended dose is 100 mg once daily (two 50 mg tablets).
However, in cases of severe hypertension, a higher dosage may be necessary.
The combination with other antihypertensive therapies, for example with diuretics, is possible.
- In case of renal insufficiency, the dosage is adjusted to the values ​​of serum creatinine or creatinine clearance (Clcr):
. serum creatinine <25 mg / L (= 35 ml / min / 1.73 m²: unchanged dose (2 x 50 mg / day) once.
. serum creatinine 25-50 mg / L (0.3-0.6 mmol / L) / 15 Clcr <35 mL / min / 1.73 m²: 1 x 50 mg / day.
. serum creatinine> 50 mg / L (> 0.6 mmol / L) / CrCl <15 ml / min / 1.73 m²: 1 x 25 mg / day, ie 1/2 tablet per day of ATENOLOL GNR 50 mg or 1 x 50 mg every other day.
. chronic hemodialysis: treatment initiated in hospital: 50 mg after each session.

Against indications

CONTRAINDICATED:
This medicine MUST NEVER be used in the following cases:
- hypersensitivity to atenolol,
- asthma and obstructive chronic bronchopneumopathies in their severe forms,
- heart failure not controlled by treatment,
- cardiogenic shock,
- atrioventricular blocks of the second and third degrees not paired,
- Prinzmetal's angina (in pure forms and monotherapy),
- sinus disease (including sinoatrial block),
- bradycardia (<45-50 beats per minute),
- Raynaud's phenomenon and peripheral arterial disorders in their severe forms,
- untreated pheochromocytoma,
- hypotension,
- history of anaphylactic reaction,
- combination with floctafenine, sultopride (see interactions).
Due to the presence of lactose, this drug is contraindicated in cases of congenital galactosemia, glucose-galactose malabsorption syndrome or lactase deficiency.
NOT RECOMMENDED :
- This drug is generally not recommended when combined with amiodarone (see interactions).
- Breast-feeding: Beta-blockers are excreted in the milk. The risk of developing hypoglycaemia and bradycardia has not been evaluated. Therefore, as a precaution, it should be avoided in women who are breastfeeding.

Adverse effects Atenolol Gnr

- Clinically:
The most frequently reported :
. asthenia,
. cooling of the ends,
. bradycardia, severe if any,
. digestive disorders (gastralgia, nausea, vomiting),
. incapacity.
Much less often :
. slowing of atrioventricular conduction or intensification of an existing atrioventricular block,
. heart failure,
. blood pressure drop,
. bronchospasm,
. hypoglycemia,
. Raynaud's syndrome,
. worsening of existing intermittent claudication,
. various skin manifestations including psoriasiform eruptions.
- Biologically:
In rare cases, it has been possible to observe the appearance of antinuclear antibodies which only exceptionally accompany clinical manifestations such as lupus syndrome and cede at the end of treatment.
Exceptional elevations of hepatic transaminases (as well as some cases of intrahepatic cholestasis).

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