Medicinal Products

ASPIRIN VITAMIN B1 C DEROL 400 mg

Generic drug of the therapeutic class: Analgesics
active ingredients: Acetylsalicylic acid, Ascorbic acid, Thiamine
laboratory: Substipharm

Compressed
Box of 20
All forms

Indication

- Symptomatic treatment of mild to moderate pain and / or febrile conditions.
- Rheumatic diseases.
Note: The analgesic benefit of the combination with vitamin B1 is not demonstrated.

Dosage ASPIRINE VITAMIN B1 C DEROL 400 mg Tablet Box of 20

Reserved for adults and children from 35 kg (about 12 years old).
Oral way.
Dissolve the tablet in a glass of water.
Systematic catches prevent peaks of fever or pain. They must be spaced at least 4 hours apart.
- Pains of mild to moderate intensity and / or febrile states:
. Adult :
As an indication: 1 tablet 400 mg, to renew if necessary after 4 hours. In case of more intense pain, 2 tablets at 400 mg per dose, without exceeding the dose of 7 tablets per day. The maximum daily dosage is 3 g.
. Elderly :
As an indication: 1 400 mg tablets, to be renewed if necessary after 4 hours, without exceeding the dose of 5 tablets per day. The maximum daily dosage is 2 g.
. Child : The maximum daily dosage in children is 50 mg / kg.
Between 35 and 50 kg (approximately between 12 to 15 years): 1 tablet to 400 mg, to renew if necessary after 4 hours, without exceeding 5 tablets per day. Approximate ages by weight are indicative.
- Rheumatic diseases:
. Adults : The daily dosage is 4 to 6 g to be divided in the day in 3 or 4 doses.
. Children : The maximum daily dose is 100 mg / kg divided into 6 doses.

Against indications

CONTRAINDICATED:
This medicine is CONTRAINDICATED in the following situations:
- proven allergy to salicylates and substances of close activity: especially nonsteroidal anti-inflammatory drugs,
- hypersensitivity to vitamin B1,
- evolving gastroduodenal ulcer,
- any constitutional or acquired haemorrhagic disease,
- haemorrhagic risk.
- This drug when given in doses analgesic, antipyretic or anti-inflammatory (> = 500 mg / intake and per day) is contraindicated from the sixth month of pregnancy: from the 6th month of pregnancy, aspirin with analgesic, antipyretic or anti-inflammatory doses> = 500 mg / dose per day), like all prostaglandin synthesis inhibitors, may expose: the fetus to cardiopulmonary toxicity with premature closure of the ductus arteriosus and pulmonary hypertension renal dysfunction up to renal failure with oligohydramnios; the mother and the child, at the end of pregnancy, to a longer bleeding time. This anti-aggregating effect can occur even at very low doses. As a result, from the 6th month of pregnancy: except for extremely limited cardiological or obstetric uses, which warrant specialized surveillance, any aspirin-based medication is CONTRAINDICATED as of the 6th month.
- The onset of asthma attack, in some subjects, may be related to an allergy to nonsteroidal anti-inflammatory drugs or aspirin. In this case, this medicine is contraindicated.
- Aspirin is contraindicated with methotrexate if it is used at doses higher than 15 mg / week.
- When administered at high doses (> = 3 g / d), aspirin is contraindicated with oral anticoagulants.
NOT RECOMMENDED :
- Aspirin is not recommended in case of gout.
- The use of this drug is not recommended when breastfeeding: aspirin passes into breast milk, breastfeeding is not recommended.
- Aspirin should generally not be used in combination with:
. oral anticoagulants (for doses of aspirin <3 g / day in adults),
. other NSAIDs (for high doses of aspirin or> = 3 g / day in adults),
. heparin,
. ticlopidine,
. uricosurics (see interactions).

Side effects Aspirin Vitamin B1 C Derol

- Effects on the central nervous system:
. ear buzzing,
. feeling of loss of hearing,
. headaches that are usually the hallmark of an overdose.
- Gastrointestinal effects:
. gastric ulcers,
. obvious digestive bleeding, (hematemesis, melena ...) or occult, responsible for an iron deficiency anemia. These haemorrhages are all the more frequent as the dosage is higher.
- Hematological effects:
hemorrhagic syndromes (epistaxis, gingivorragies, purpura ...) with increased bleeding time. This action persists for 4 to 8 days after stopping aspirin. It can create a hemorrhagic risk, in case of surgical intervention.
- Hypersensitivity reaction:
sensitization accidents: Quincke's edema, urticaria, asthma, anaphylactic accidents.
- Other: abdominal pain.

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