Medicinal Products

ASPIRINE RATIOPHARM 500 mg

Generic drug of the therapeutic class: Analgesics
active ingredients: Acetylsalicylic acid
laboratory: Ratiopharm Gmbh

Tablet breackable
Box of 50
All forms

Indication

- Symptomatic treatment of mild to moderate pain and / or febrile conditions.
- Chronic inflammatory rheumatism, rheumatic fever in children.
- Symptomatic treatment of inflammatory rheumatism in adults.

Dosage ASPIRINE RATIOPHARM 500 mg Tablet breakable Box of 50

Administration mode :
Oral way.
The tablets may be swallowed without being chewed or dissolved in water before swallowing, preferably before or during a meal, even if light.
Dosage:
LOW INTENSITY PAIN IN MODERATE AND / OR FEBRILES CONDITIONS:
Reserved for adults and children over 6 years and weighing more than 21 kg .
- For adults and children weighing more than 50 kg (from about 15 years old):
The maximum recommended daily dosage is 3 g of acetylsalicylic acid, 6 tablets per day.
The usual dosage is 1 500 mg tablet, to be renewed if necessary after a minimum of 4 hours. In case of pain or fever more intense, 2 tablets 500 mg, to renew if necessary after 4 hours minimum, without exceeding 6 tablets per day .
- For elderly subjects :
The maximum recommended daily dosage is 2 g of acetylsalicylic acid, 4 tablets per day.
The usual dosage is 1 500 mg tablet, to be renewed if necessary after a minimum of 4 hours. In case of pain or fever more intense, 2 tablets to 500 mg, to renew when necessary after 4 hours minimum, without exceeding 4 tablets per day .
- In children over 6 years old and weighing between 21 kg and 50 kg (up to about 15 years):
In children, it is imperative to respect the dosages defined according to the weight of the child and to choose a suitable presentation. Approximate ages by weight are given for information.
The recommended daily dose of acetylsalicylic acid is approximately 60 mg / kg, divided into 4 to 6 doses, approximately 15 mg / kg every 6 hours or 10 mg / kg every 4 hours.
. For children over 6 years and a weight of 21 to 27 kg (up to about 10 years), the dosage is 1/2 tablet per dose, to be renewed if necessary after 4 hours, without exceeding 6 once 1/2 tablet a day .
. For children weighing 28 to 40 kg (approximately 9 to 13 years), the dosage is 1 tablet per dose, to be renewed if necessary after 6 hours, without exceeding 4 tablets per day .
. For children weighing 41 to 50 kg (approximately 12 to 15 years), the dosage is 1 tablet per dose, to be renewed if necessary after 4 hours, without exceeding 6 tablets per day .
Frequency of administration:
Systematic catches prevent pain or fever oscillations:
. In adults: catches should be spaced at least 4 hours apart.
. In children (from over 21 kg to 50 kg, more than 6 years up to 15 years): the catches must be
regularly spaced, including at night : adhere to the dosage specified above.
Duration of treatment: Acetylsalicylic acid should not be used for more than 3-5 days without the advice of a doctor or dentist.
RHEUMATIC DISORDERS:
Reserved for adults and children over 6 years old .
- In adults:
3 to 6 g maximum per day to be divided into 3 or 4 taken at least 4 hours apart.
- In the elderly, the dosage will be reduced.
- In children over 6 years old:
50 mg / kg to 100 mg / kg maximum per day to be divided into 4 to 6 times at least 4 hours apart.

Against indications

CONTRAINDICATED:
This medicine is CONTRAINDICATED in the following situations:
- hypersensitivity to acetylsalicylic acid or to any of the excipients,
- history of asthma caused by the administration of salicylates or substances of similar activity,
especially nonsteroidal anti-inflammatory drugs,
- child under 6 years old: risk of a false trip; use another presentation,
- evolving gastroduodenal ulcer,
- any constitutional or acquired haemorrhagic disease,
- haemorrhagic risk,
- severe hepatic insufficiency,
- severe renal insufficiency,
- severe uncontrolled heart failure,
- last trimester of pregnancy (> = 500 mg per day and per dose): Acetylsalicylic acid at doses greater than or equal to 500 mg per dose and per day, like all prostaglandin synthesis inhibitors, may expose the fetus to cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension); renal dysfunction up to renal failure with oligohydramnios; the mother and the child, at the end of pregnancy, to a longer bleeding time. This anti-aggregating effect can occur even at very low doses. As a result, apart from extremely limited cardiological or obstetric uses, which warrant medical advice and specialized monitoring, any drug containing acetylsalicylic acid is contraindicated during the last trimester of pregnancy.
- combination with methotrexate at doses greater than or equal to 15 mg / week,
- combination with oral anticoagulants when salicylates are used in high doses (> = 3 g / day in adults) especially in the treatment of rheumatic diseases.
NOT RECOMMENDED :
Breast-feeding: As acetylsalicylic acid passes into breast milk, this drug is not recommended during breastfeeding.
Associations advised against : oral anticoagulants with low-dose salicylates, other NSAIDs for salicylates in high doses (> = 3 g / day in adults), parenteral heparins, ticlopidine, uricosurics (such as benzbromarone, probenecid).

Side effects Aspirine Ratiopharm

- Gastrointestinal effects:
. abdominal pain,
. obvious digestive bleeding, (hematemesis, melena ...) or occult, responsible for an iron deficiency anemia. These haemorrhages are all the more frequent as the dosage is higher,
. gastric ulcers and perforations.
- Effects on the central nervous system:
. headache, dizziness,
. feeling of loss of hearing,
. ear buzzing,
which are usually the mark of an overdose.
- Hematological effects:
hemorrhagic syndromes (epistaxis, gingivorragies, purpura, ...) with increased bleeding time. This action persists for 4 to 8 days after stopping acetylsalicylic acid. It can create a hemorrhagic risk, in case of surgical intervention.
- Hypersensitivity reaction:
urticaria, skin reactions, anaphylactic reactions, asthma, Quincke's edema.
- Reye's syndrome (see warnings and precautions for use: persistent vomiting, disturbances of consciousness, abnormal behavior).

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