Medicinal Products

APOKINON 10 mg / ml 1%

Generic Drug Therapeutic Class: Neurology-Psychiatry
active ingredients: Apomorphine
laboratory: Aguettant

SC Injection Solution
Box of 50 ampoules of 5 ml
All forms

Indication

Adjunctive therapy for severe fluctuations in dopa therapy activity during Parkinson's disease (on-off phenomenon).

Dosage APOKINON 10 mg / ml 1% Solution for injection SC Box of 50 ampoules of 5 ml

Subcutaneous route: continuous subcutaneous infusion.

Initial rate of 1 mg / hour, adaptable according to the clinical results.

Against indications

This medicine is contraindicated in case of:

Hypersensitivity to apomorphine or other excipients of the product,

· Hepatic insufficiency,

· intellectual disability,

· mental confusion,

· Psychotic manifestations,

· Combination with anti-emetic neuroleptics (see section Interactions with other medicinal products and other forms of interaction ).

Adverse effects Apokinon 10 MG / ML

· Somnolence has been reported during treatment with apomorphine

· Nausea, vomiting,

· orthostatic hypotension,

· Tiredness, pallor, salivation, sweating,

· Psychic disorders which have to reduce the dosage, or even interrupt the treatment,

· Pruritus at injection sites,

· Possibility of inflammatory subcutaneous nodules (see Warnings and precautions for use section ),

· Due to the presence of sodium metabisulfite, risk of allergic reactions, including anaphylactic reactions and bronchospasm,

· Cases of pathological gambling, hypersexuality and increased libido have been reported since marketing (see Warnings and Precautions section ).

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