Medicinal Products

AMOXICILLIN EG 125 mg / 5 mL

Clamoxyl Generic Drug
Therapeutic class: Infectiology - Parasitology
active ingredients: Amoxicillin
laboratory: EG Labo

Powder for oral suspension
Bottle of reconstituted suspension of 60 ml
All forms

Indication

They result from the antibacterial activity and the pharmacokinetic characteristics of amoxicillin. They take into account both the clinical studies that gave rise to this drug and its place in the range of antibacterial products currently available.
- They are limited to infections due to germs defined as sensitive:
IN ADULT AND CHILD :
- in initial treatment of:
. acute pneumopathies, . superinfections of acute bronchitis and exacerbations of chronic bronchitis,
. ENT infections (otitis, sinusitis, documented angina at beta-hemolytic streptococcus A) and stomatology,
. urinary tract infections,
. male genital infections and gynecological infections,
. digestive and biliary infections, . Lyme disease: treatment of the primary phase (chronic erythema migrans) and the primosecondary phase (chronic erythema migrans associated with general signs: asthenia, headache, fever, arthralgia ...), - relay treatment of the injectable route endocarditis, septicemia,
- as a prophylactic treatment of bacterial endocarditis. ON ADULTS ONLY : in combination with another antibiotic (clarithromycin or imidazole) and antisecretory agent, eradication of Helicobacter pylori in adult peptic ulcer disease. - Official recommendations regarding the proper use of antibacterials should be taken into account.

Dosage AMOXICILLINE EG 125 mg / 5 mL Powder for oral suspension 60 ml reconstituted suspension bottle

- One measuring spoon (5 ml) contains 125 mg of amoxicillin.
- There are other presentations of amoxicillin that are more suitable for adults and other presentations more appropriate in some cases to the child (large doses, older children). Dosage : IN THE SUBJECT NORMAL RENALE FUNCTION:
ADULT :
The usual dosage is 1-1.5 or 2 g / day in 2 to 3 doses.
SPECIAL CASES :
- Angina : 2 g / day in 2 daily doses.
The treatment duration of angina is 6 days.
- Acute pneumopathies : 3 g / day, ie 1 g every 8 hours.
- Lyme disease :
. Chronic erythema migrans strictly isolated: 4 g / day.
. in case of systemic manifestations suggestive of hematogenous spread of Borrelia burgdorferi, the dosage may be increased up to 6 g / day.
The duration of treatment will be 15 to 21 days.
- Endocarditis and septicemia (relay of the injectable route) : the dosage can be increased up to 6 g per 24 hours in at least three doses.
- Prophylaxis of bacterial endocarditis :
. oral protocol: 3 g taken once, given within one hour before the risky procedure,
. relay parenteral protocol: 1 g per os 6 hours after parenteral administration.
- Eradication of Helicobacter pylori in cases of peptic ulcer disease : the following dosing regimens are recommended:
. amoxicillin 1 g morning and evening, combined with clarithromycin 500 mg morning and evening and omeprazole 20 mg morning and evening for 7 days, then 20 mg omeprazole daily for 3 additional weeks in case of progressive duodenal ulcer or 3 to 5 weeks in case of progressive gastric ulcer,
or
. amoxicillin 1 g morning and evening, combined with clarithromycin 500 mg morning and evening and lansoprazole 30 mg morning and evening, for 7 days, then 30 mg lansoprazole daily for 3 additional weeks in case of progressive duodenal ulcer or 3 to 5 weeks in case of progressive gastric ulcer.
The effectiveness of the treatment depends on compliance with the dosing regimen, including the taking of triple therapy during the first 7 days.
CHILD :
- The usual dosage is as follows:
. for children under 30 months of age : 50 mg / kg / day at 100 mg / kg / day in 3 divided doses at 8 hours,
. for children older than 30 months : 25 mg / kg / day at 50 mg / kg / day in 2 or better 3 doses without exceeding the dosage of 3 g / day.
- In other infections, the recommended dosage is 80 to 100 mg / kg / day in 3 doses.
. Otitis media acute :
If a 72-hour probabilistic treatment and bacteriological documentation of a Streptococcus pneumoniae with decreased susceptibility to penicillin G fails, the recommended dosage is 150 mg / kg / day in 3 divided doses for 10 days. Up-to-date clinical data have shown bacterial eradication at this dose for S. pneumoniae strains with amoxicillin MIC <= 2 mg / L.
. Pneumonia .
- For more severe infections, as well as for endocarditis and septicemia (in relay of the injectable route): the dosage can be increased up to 150 mg / kg / day in 3 or 4 doses, without exceeding the dosage of 6 g /day.
SPECIAL CASES :
- Angina : in children older than 30 months: 50 mg / kg / day, in 2 daily doses. The treatment duration of angina is 6 days.
- Lyme disease :
. strictly isolated chronic migrating erythema: 50 mg / kg / day,
. in case of systemic manifestations suggestive of hematogenous spread of Borrelia burgdorferi, the dosage may be increased up to 100 mg / kg / day without exceeding 6 g / day.
The duration of treatment will be 15 to 21 days.
- Prophylaxis of bacterial endocarditis :
. oral protocol: 75 mg / kg once taken, administered within one hour before the risky procedure;
. parenteral protocol relay: 25 mg / kg orally 6 hours after parenteral administration.
IN THE INSUFFICIENT RENAL SUBJECT:
Administer a first loading dose (Do) equivalent to the dose normally prescribed and, depending on the degree of severity of the pathology:
Creatinine clearance: Dosage regimen .
- greater than 30 ml / min: No adaptation: continue the treatment with the usual dose and the recommended frequency.
- from 10 to 30 ml / min: Do / 2, every 12 hours.
- less than 10 ml / min: Do / 2, every 24 hours.
Hemodialysis: Do then Do / 2 a day. On days of dialysis, administer Do / 2 after the dialysis session. Mode of administration : ORAL ROUTE.
- This medicine can be taken during or between meals.
- Use the measuring spoon supplied with the bottle.

Against indications

CONTRAINDICATED:
- This medicine MUST NEVER BE USED:
in case of allergy to antibiotics of the beta-lactam family (penicillins and cephalosporins) or any of the other ingredients. - This drug is contraindicated in patients with fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltase deficiency (rare hereditary diseases). NOT RECOMMENDED :
This medicine SHOULD NOT BE USED in combination with methotrexate (see interactions).

Adverse effects Amoxicillin EG

- The classification of adverse effects used is as follows:
very common:> = 1/10.
frequent:> = 1/100; <1/10.
uncommon:> = 1/1000; <1/100.
rare:> = 1/10000; <1/1000.
very rare: <1/10000.
indeterminate frequency: can not be estimated based on available data.
- Hematological and lymphatic system disorders:
. Very rare : leukopenia, neutropenia, agranulocytosis, thrombocytopenia and reversible haemolytic anemia.
. Not known : eosinophilia.
- disorders of the nervous system:
. Very rare : convulsions.
. Not known : vertigo, headache.
- Gastrointestinal disorders:
. Common : diarrhea, nausea
. Uncommon : vomiting.
. Very rare : pseudomembranous colitis, hemorrhagic colitis.
. Not known : superficial tooth staining in children, usually reversible after brushing teeth.
- Renal and urinary disorders:
Not known : acute interstitial nephritis and crystalluria.
- Skin and subcutaneous tissue disorders:
. Common : rash
. Uncommon : urticaria and pruritus.
. Very rare : erythema multiforme, Stevens-Johnson syndrome, Lyell's syndrome, bullous or exfoliative dermatitis. These skin manifestations may be more frequent and / or more intense in patients with infectious mononucleosis or evolving lymphoid leukemia. Generalized acute exanthematous pustulosis (see warnings and precautions for use).
- Infections and infestations:
Common : cutaneous and mucous candidiasis
- Immune system disorders:
. Very rare : anaphylaxis (including anaphylactic shock), serum sickness and hypersensitivity vasculitis (see warnings and precautions for use).
. Not known : allergic manifestations, including urticaria, angioedema, respiratory discomfort.
- Hepatobiliary disorders:
. Very rare : hepatitis, cholestatic jaundice.
. Not known : moderate and transient increase in serum transaminases (ALT and / or ASAT). - Due to the presence of sorbitol, this medicine may cause mild laxative effect.

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