Medicinal Products

ADREXAN LP 80 mg

Generic drug of the therapeutic class: Cardiology and angiology
active ingredients: Propranolol
laboratory: EG Labo

Sustained-Release Capsule
Box of 28
All forms

Indication

- Hypertension.
- Prophylaxis of stress angina attacks.
- Long-term treatment after myocardial infarction.
- Reduction or prevention of sympathetic-dependent rhythm disorders: sinus or junctional tachycardias, tachycardias of atrial fibrillations and flutters, certain tachycardias of ventricular origin.
- Cardiovascular manifestations of hyperthyroidism and intolerance to replacement therapy for hypothyroidism.
Functional signs of obstructive cardiomyopathy.
- Background treatment of migraine.

Dosage ADREXAN LP 80 mg Prolonged-release capsule Box of 28

The particular bioavailability of propranolol in ADREXAN LP 80 mg capsules (see pharmacokinetic properties) allows the following dosages:
- Hypertension, prophylaxis of effort angina attacks, obstructive cardiomyopathy: One capsule at 80 mg per day, preferably in the morning.
However, in some patients, it may be necessary to increase the dosage up to 2 capsules per day. In some hypertensives, it may be possible to combine another antihypertensive or a diuretic.
- Long-term treatment after myocardial infarction:
. initial treatment : it should be instituted between the 5th and the 21st day after the acute episode of infarction: 1 40 mg tablet 4 times a day for 2 to 3 days.
. maintenance treatment : 1 capsule at 80 mg per day in the morning.
- Migraines, rhythm disorders, hyperthyroidism:
As active doses may vary from one patient to another, and doses below 80 mg may be effective, treatment with the conventional release form should be initiated.

Against indications

CONTRAINDICATED:
- hypersensitivity to propranolol,
- asthma and obstructive chronic bronchopneumopathies,
- heart failure not controlled by treatment,
- cardiogenic shock,
- atrioventricular blocks of 2nd and 3rd degrees not paired,
- angina of Prinzmetal,
- sinus disease (including sinoatrial block),
- bradycardia (<45-50 contractions per minute),
- Raynaud's phenomenon and peripheral arterial disorders,
- untreated pheochromocytoma,
- hypotension,
- history of anaphylactic reaction,
- combination with floctafenine, sultopride (see interactions).
NOT RECOMMENDED :
- This drug is generally not recommended when combined with amiodarone (see interactions).
- Breast-feeding: Beta-blockers are excreted in the milk. The risk of hypoglycaemia and bradycardia has not been evaluated: therefore, as a precautionary measure, it should be avoided in women who are breastfeeding.

Adrexan LP Adverse Reactions

Clinically:
The most frequently reported :
- asthenia,
- cooling of the ends,
- bradycardia, severe if any,
- digestive disorders (gastralgia, nausea, vomiting),
- impotence,
- insomnia, nightmares.
Much less often :
- slowing of atrioventricular conduction or intensification of an existing atrioventricular block,
- heart failure,
- blood pressure drop,
- bronchospasm,
- hypoglycemia,
- Raynaud's syndrome,
- aggravation of an existing intermittent claudication,
- various skin manifestations including psoriasiform eruption s.
Biologically:
In rare cases, it has been possible to observe the appearance of antinuclear antibodies that only exceptionally accompany clinical manifestations such as lupus syndrome and that cease when the treatment is stopped.

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