Medicinal Products

ADREXAN 40 mg

Generic drug of Avlocardyl
Therapeutic class: Cardiology and angiology
active ingredients: Propranolol
laboratory: EG Labo

Compressed
Box of 50
All forms

Indication

- Hypertension.
- Prophylaxis of stress angina attacks.
- Long-term treatment after myocardial infarction.
- Reduction or prevention of sympathetic-dependent rhythm disorders: sinus or junctional tachycardias, tachycardias of atrial fibrillations and flutters, certain tachycardias of ventricular origin.
- Cardiovascular manifestations of hyperthyroidism and intolerance to replacement therapy for hypothyroidism.
Functional signs of obstructive cardiomyopathy.
- Background treatment of migraine and facial pain.
- Tremors especially essential.

Dosage ADREXAN Ge 40 mg Tablet Box of 50

- Hypertension, prophylaxis of effort angina attacks, obstructive cardiomyopathy:
4 tablets daily in 2 doses (160 mg) on ‚Äč‚Äčaverage.
The treatment can possibly be initiated by 2 tablets.
- Long-term treatment after myocardial infarction:
. Initial treatment : It must be instituted between the 5th and the 21st day after the acute episode of infarction; 1 40 mg tablet 4 times daily for 2 to 3 days.
. Maintenance treatment : 4 tablets daily in 2 doses (160 mg per day).
- Rhythmic disorders and hyperthyroidism: 1 to 2 tablets daily in several doses.
- Migraines, facial pain, trembling: 1 to 3 tablets a day.

Against indications

CONTRAINDICATED:
- Hypersensitivity to propranolol.
- Asthma and chronic obstructive bronchopneumopathies.
- Heart failure not controlled by treatment.
- Cardiogenic shock.
- Atrioventricular blocks of the 2nd and 3rd degrees not paired.
- Angor of Prinzmetal.
- Sinus disease (including sinoatrial block).
- Bradycardia (<45-50 beats per minute).
- Phenomenon of Raynaud and peripheral arterial disorders.
- Untreated pheochromocytoma.
- Hypotension.
- Antecedent of anaphylactic reaction.
- Association with floctafenine, sultopride (see interactions).
- In the context of primary and secondary prevention of digestive hemorrhages in cirrhotic patients: advanced hepatic insufficiency with hyperbilirubinemia, massive ascites, hepatic encephalopathy.
NOT RECOMMENDED :
- This drug is generally not recommended when combined with amiodarone (see interactions).
- Breast-feeding: Beta-blockers are excreted in the milk. The risk of developing hypoglycaemia and bradycardia has not been evaluated; therefore, and as a precautionary measure, it should be avoided in women who are breastfeeding.

ADREXAN side effects

Clinically:
Most remembered :
- asthenia,
- cooling of the ends,
- bradycardia, severe if any,
- digestive disorders (gastralgia, nausea, vomiting, diarrhea),
- incapacity,
- insomnia, nightmares.
Much less often :
- slowing of atrioventricular conduction or intensification of an existing atrioventricular block,
- heart failure,
- blood pressure drop,
- bronchospasm,
- hypoglycemia,
- Raynaud's syndrome,
- aggravation of an existing intermittent claudication,
- various skin manifestations including psoriasiform eruptions.
Biologically:
In rare cases, it has been possible to observe the appearance of antinuclear antibodies which only exceptionally accompany clinical manifestations such as lupus syndrome and cede at the end of treatment.

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