Generic drug of the therapeutic class: Allergology
Active ingredients: Adrenaline
Box of 10 ampoules of 1 mL
· Treatment of cardiovascular arrest;
· Treatment of anaphylactic shock;
· Treatment of cardio-circulatory distress with states of anaphylactic, hemorrhagic, traumatic, infectious or secondary shock to cardiac surgery.
Dosage ADRENALINE AGUET SULFITE FREE 1 mg / mL Solution for injection Box of 10 ampoules of 1 mL
Treatment of cardiac arrest:
Lane IV : 1 mg bolus (1 ml) every 3 to 5 minutes until recovery of hemodynamic status.
The tracheobronchial route can be used as an alternative to the IV route, at a dosage of 3 mg (3 ml) diluted in 10 ml of 0.9% sodium chloride solution, in a single dose.
Infants and children:
Route IV : in bolus of 0.01 mg / kg, then if necessary, an additional dose of 0.1 mg / kg every 3 to 5 minutes until recovery of the hemodynamic state.
The tracheobronchial route can be used as an alternative to the IV route, at a dosage of 0.1 to 0.3 mg / kg, as a single dose.
Treatment of established anaphylactic shock:
IM route : 0.5-1 mg (0.5-1 ml), repeated every 5 minutes if necessary.
Lane IV : dilution of 1 ml (ie 1 mg) in 10 ml of 0.9% sodium chloride solution and intravenous bolus administration of 1 ml of the diluted solution, ie 0.1 mg of adrenaline. The boluses will be repeated until the haemodynamic state is restored. Close supervision will be established.
SC route : 0.3 ml of the solution (undiluted) or 0.3 mg of adrenaline. The improvement usually occurs within 3 to 5 minutes after the subcutaneous injection. A second injection of 0.3 ml of the solution (undiluted) can be made 10 to 15 minutes later if necessary.
Infants and children
Doses will be in children, IM or subcutaneously (0.01 mg / kg)
· Less than 2 years (up to 12 kg): 0.05 to 0.1 ml of the solution (undiluted), ie 0.05 to 0.1 mg of adrenaline,
· From 2 to 6 years (12-18 kg): 0.15 ml of the solution (undiluted), ie 0.15 mg of adrenaline,
· 6 to 12 years (18 to 33 kg): 0.2 ml of the solution (undiluted) or 0.2 mg of adrenaline.
Treatment of cardio-circulatory distress with shock
Continuous electric syringe administration of a dose of between 0.01 microgram / kg / minute and 0.5 or 1 microgram / kg / minute, the average dosage being titrated according to the desired therapeutic effect.
· Rhythm disorders (especially ventricular)
· Severe obstructive cardiomyopathy
· Coronary insufficiency
This drug is indicated in emergency, these contraindications are relative.
Adrenaline Adverse Events Aguet Without Sulphite
Adverse effects depend on the patient's individual sensitivity and the dose administered.
At low doses, common side effects are: palpitations, tachycardia, sweating, nausea, vomiting, difficulty breathing, pallor, dizziness, weakness, tremors, headache, anxiety, nervousness, anxiety, cold extremities.
The less common effects are: hallucinations, syncope, hyperglycemia, hypokalemia, metabolic acidosis, mydriasis, urinary difficulty with urinary retention, muscle tremors.
In high doses or in patients sensitive to adrenaline, the adverse effects are: cardiac arrhythmia (sinus tachycardia, ventricular fibrillation / cardiac arrest), access to arterial hypertension (sometimes causing cerebral hemorrhage), vasoconstriction (for example cutaneous, mucous membranes and kidneys), angina attacks, even risk of acute myocardial infarction.